Anti-CD274 (PD-L1) Antibody Pipeline Insights | Clinical Trials Report 2022 by DelveInsight

The clinical development of anti-PD-L1 agents is at the epicenter of immuno-oncology drug development. The clinical success of monoclonal antibodies targeting PD-L1 is an attractive lure, and drug development in this sphere continues at a robust pace. The Anti-CD274 (PD-L1) Antibody pipeline constitutes 80+ key companies proactively working to develop 80+ key therapies, asserts DelveInsight.

DelveInsight’s Anti-CD274 (PD-L1) Antibody Pipeline Insight 2022 report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, major pharmaceutical companies working to advance the pipeline space, and future growth potential of the Anti-CD274 (PD-L1) Antibody pipeline domain. 

Some of the essential takeaways from the Anti-CD274 (PD-L1) Antibody Pipeline report:

  • DelveInsight’s Anti-CD274 (PD-L1) Antibody Pipeline analysis depicts a robust space with 80+ active players working to develop 80+ pipeline treatment therapies. 
  • Some of the key pharmaceutical companies working to develop potential drug candidates to improve the Anti-CD274 (PD-L1) Antibody treatment scenario include Compass Therapeutics, Curis, Biotheus, RemeGen, Incyte Corporation, Jubilant Therapeutics, ChemoCentryx, ABL Bio, Chia Tai Tianqing Pharmaceutical, Jiangsu Hengrui Medicine, Sorrento Therapeutics, CStone Pharmaceuticals, Celgene, Checkpoint Therapeutics, Alphamab Oncology, Eli Lilly and Company, Novartis Pharmaceuticals, Aurigene Discovery Technologies, Arbutus Biopharma, CytomX Therapeutics, Genmab A/S, Secarna Pharmaceuticals, Avacta Life Sciences Limited, Fate Therapeutics, Hanmi Pharm.Co., Ltd., Celldex Therapeutics, Bolt Biotherapeutics, Bio-Thera Solutions, Acepodia Inc., Janux Therapeutics, Coherus Biosciences, Effector Therapeutics, Palleon Pharmaceuticals, F-star Therapeutics, BeiGene, and many others.
  • Essential Anti-CD274 (PD-L1) Antibody pipeline therapies such as CTX-8371, CA 327, RC 98, PM 8001, INCB086550, CCX 559, ABL501, TQB 2450, SHR 1316, FS222, SHR-1701, Cosibelimab, LY 3434172,  KN035, KN046, CX-072, GEN1046, AVA028, AVA021, PD-L1 XT, FT516, FT500, CDX 527, Envafolimab, BGB-A333, ACE1708, Tomivosertib, and others are under development in different phases of clinical trials.
  • In November 2021, Sorrento Therapeutics announced that its license partner, China Oncology Focus Limited (COF), an affiliate of Lee's Pharmaceutical Holdings Limited has submitted an NDA (new drug application) for the anti-PD-L1 antibody, socazolimab, licensed from Sorrento to COF for the greater China territory to treat recurrent or metastatic cervical cancer. The NDA application has been accepted by China NMPA. In February 2021, Sorrento and Lee's Pharma announced that socazolimab had been granted breakthrough designation by the NMPA.
  • In December 2021, Checkpoint Therapeutics announced the initiation of the CONTERNO study, a global, randomized Phase 3 trial of cosibelimab in combination with pemetrexed and platinum chemotherapy for the first-line treatment of patients with non-squamous non-small cell lung cancer (NSCLC). The primary endpoint for the CONTERNO Phase 3 trial is overall survival (OS), and the study is designed to support full regulatory approvals worldwide.
  • In August 2021, ABL Bio announced that the Investigational New Drug (IND) application for ABL501 has been approved by South Korea's Ministry of Food and Drug Safety (MFDS).
  • In December 2021, Biotheus Inc. announced that its proprietary anti-PD-L1/TGF-β bifunctional therapeutic, named PM8001, has been approved by the USFDA (United States Food and Drug Administration) for conducting clinical phase II studies as part of an international multicenter clinical trial.
  • In September 2021, Chia Tai Tianqing Pharmaceutical Group initiated a Phase III clinical study to evaluate the efficacy and safety of TQB2450 injection combined with Anlotinib Hydrochloride capsules versus weekly treatment with paclitaxel of recurrent platinum-resistant ovarian cancer. The trial is currently active with 405 participants and is anticipated to be completed by December 2024.
  • In June 2021, Alphamab Oncology announced that FDA approved an Orphan Drug Designation (ODD) to envafolimab (KN035), a recombinant humanized PD-L1 single-domain antibody independently invented by Alphamab Oncology, for the treatment of patients with soft tissue sarcoma. This is the second Orphan Drug Designation for Envafolimab after its first ODD in advanced biliary tract cancer and the fourth ODD that Alphamab Oncology has obtained from the U.S. FDA.

View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight

Request a sample and discover more about the report offerings @ Anti-CD274 (PD-L1) Antibody Emerging Therapies

The Anti-CD274 (PD-L1) Antibody pipeline report lays down detailed profiles of the pipeline assets, comparative analysis of clinical and non-clinical stage Anti-CD274 (PD-L1) Antibody products, inactive and dormant assets, comprehensive assessment of driving and restraining factors, as well as the opportunities and risks in the Anti-CD274 (PD-L1) Antibody pipeline landscape.

Anti-CD274 (PD-L1) Antibody Overview

Programmed death-ligand 1 (PD-L1; and its partner PD-L2) is a transmembrane protein expressed in normal tissues to inhibit the activity of T-cells and prevent autoimmunity. PD-L1 is commonly upregulated on the surface of tumor cells, binding to the programmed death 1 (PD-1) expressed on tumor-infiltrating lymphocytes, eventually causing a T-cell tolerance. This represents one of the various mechanisms of immune evasion. The molecular organization of PD-L1 is similar to that of other B7 molecules and typical of the immunoglobulin superfamily. PD-L1 is constitutively expressed at varying levels in cells of the myeloid lineage, such as DCs, macrophages, and myeloid-suppressor cells (MDSCs) but also in other cell types.

Find out more about the disease and recent developments @ Anti-CD274 (PD-L1) Antibody Pipeline Assessment

View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight

Anti-CD274 (PD-L1) Antibody Pipeline Drugs

Drug

Company

Phase

MoA

RoA

CTX-8371

Compass Therapeutics

Preclinical

Programmed cell death-1 ligand-1 inhibitors

NA

CA 327

Curis

Preclinical

Programmed cell death-1 ligand-1 inhibitors

Oral

RC 98

RemeGen 

Phase I

Programmed cell death-1 ligand-1 inhibitors

Parenteral

LY 3434172

Eli Lilly and Company

Phase I

Programmed cell death-1 ligand-1 inhibitors

Intravenous

INBRX-105

Inhibrx

Phase I

Programmed cell death-1 ligand-1 inhibitors

Parenteral

CDX 527

Celldex Therapeutics Inc

Phase I

Programmed cell death-1 ligand-1 inhibitors

Parenteral

PM 8001

Biotheus

Phase II

Programmed cell death-1 ligand-1 inhibitors

Parenteral

INCB086550

Incyte Corporation

Phase II

Programmed cell death-1 ligand-1 inhibitors

Oral

CX-072

CytomX Therapeutics

Phase II

Programmed cell death-1 ligand-1 inhibitors

Intravenous

Tomivosertib

Effector Therapeutics

Phase II

Programmed cell death-1 ligand-1 inhibitors

Oral

Research program: programmed cell death 1 ligand 1 inhibitors

Jubilant Therapeutics

Preclinical

Programmed cell death-1 ligand-1 inhibitors

NA

CCX 559

ChemoCentryx

Phase I

Programmed cell death-1 ligand-1 inhibitors

Oral

ABL501

ABL Bio

Phase I

Programmed cell death-1 ligand-1 inhibitors

Parenteral

TQB 2450

Chia Tai Tianqing Pharmaceutical

Phase III

Programmed cell death-1 ligand-1 inhibitors

Intravenous

SHR 1316

Jiangsu Hengrui Medicine

Phase III

Programmed cell death-1 ligand-1 inhibitors

Parenteral

SHR-1701

Jiangsu Hengrui Medicine

Phase III

Programmed cell death-1 ligand-1 inhibitors

Intravenous

Cosibelimab

Checkpoint Therapeutics

Phase III

Programmed cell death-1 ligand-1 inhibitors

Intravenous

Socazolimab

Sorrento Therapeutics

Preregistration

Programmed cell death-1 ligand-1 inhibitors

Intravenous

GB226

Genor Biopharma

Preregistration

Programmed cell death-1 ligand-1 inhibitors

Intravenous

BGB-A333

BeiGene

Phase I/II

Programmed cell death-1 ligand-1 inhibitors

Intravenous

Learn more about the novel and emerging Anti-CD274 (PD-L1) Antibody pipeline therapies @ https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight

Anti-CD274 (PD-L1) Antibody Therapeutics Assessment

The Anti-CD274 (PD-L1) Antibody Pipeline report proffers an integral view of the Anti-CD274 (PD-L1) Antibody emerging novel therapies segmented by Stage, Product Type,  Molecule Type,  Mechanism of Action, and Route of Administration.

View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight

Scope of the Anti-CD274 (PD-L1) Antibody Pipeline Report

  • Coverage: Global 
  • Therapeutic Assessment By Anti-CD274 (PD-L1) Antibody Product Type: Mono, Combination, Mono/Combination
  • Therapeutic Assessment By Anti-CD274 (PD-L1) Antibody Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III, Pre-registration,Inactive candidates
  • Therapeutics Assessment By Anti-CD274 (PD-L1) Antibody Therapeutics Route of Administration: Oral, Intravenous, Inhalation, Subcutaneous, Parenteral
  • Therapeutics Assessment By Anti-CD274 (PD-L1) Antibody Therapies Molecule Type: Gene therapy, Stem cell therapy, Small molecules
  • Therapeutics Assessment By Anti-CD274 (PD-L1) Antibody Therapies Mechanism of Action: Programmed cell death-1 ligand-1 inhibitors
  • Key Anti-CD274 (PD-L1) Antibody Companies:  Compass Therapeutics, Curis, Biotheus, RemeGen, Incyte Corporation, Jubilant Therapeutics, ChemoCentryx, ABL Bio, Chia Tai Tianqing Pharmaceutical, Jiangsu Hengrui Medicine, Sorrento Therapeutics, CStone Pharmaceuticals, Celgene, Checkpoint Therapeutics, Alphamab Oncology, Eli Lilly and Company, Novartis Pharmaceuticals, Aurigene Discovery Technologies, Arbutus Biopharma, CytomX Therapeutics, Genmab A/S, Secarna Pharmaceuticals, Avacta Life Sciences Limited, Fate Therapeutics, Hanmi Pharm.Co., Celldex Therapeutics, Bolt Biotherapeutics, Bio-Thera Solutions, Acepodia Inc., Janux Therapeutics, Coherus Biosciences, Effector Therapeutics, Palleon Pharmaceuticals, F-star Therapeutics, BeiGene, and many others.
  • Key Anti-CD274 (PD-L1) Antibody Pipeline Therapies: CTX-8371, CA 327, RC 98, PM 8001, INCB086550, CCX 559, ABL501, TQB 2450, SHR 1316, FS222, SHR-1701, Cosibelimab, LY 3434172,  KN035, KN046, CX-072, GEN1046, AVA028, AVA021, PD-L1 XT, FT516, FT500, CDX 527, Envafolimab, BGB-A333, ACE1708, Tomivosertib, and others.

Dive deep into rich insights for emerging therapies and assessment, visit @ https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight

View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight

 

Table of Contents 

1

Introduction

2

Executive Summary

3

Anti-CD274 (PD-L1) Antibody: Overview

4

Pipeline Therapeutics

5

Late Stage Products (Preregistration)

5.1

Socazolimab: Sorrento Therapeutics

5.2

GB226: Genor Biopharma

6

Late Stage Products (Phase III)

6.1

Cosibelimab: Checkpoint Therapeutics

6.2

SHR-1701: Jiangsu Hengrui Medicine

7

Mid Stage Products (Phase II)

7.1

Tomivosertib: Effector Therapeutics

7.2

INCB086550: Incyte Corporation

7.3

PM 8001: Biotheus

8

Early Stage Products (Phase I/II)

8.1

BGB-A333: BeiGene

9

Early Stage Products (Phase I)

9.1

ABL501: ABL Bio

10

Preclinical Stage Products

10.1

CTX-8371: Compass Therapeutics

11

Therapeutic Assessment

12

Inactive Products

13

Collaborations Assessment- Licensing / Partnering / Funding

14

Anti-CD274 (PD-L1) Antibody- Unmet Needs

15

Anti-CD274 (PD-L1) Antibody- Market Drivers and Barriers

16

Appendix

17

About DelveInsight

For further information on the Anti-CD274 (PD-L1) Antibody current pipeline therapeutics, reach out @ Anti-CD274 (PD-L1) Antibody Ongoing Clinical Trials

DelveInsight’s Competitive Intelligence Service includes a multidimensional coverage, helping to keep track of competitors and gain traction in the dynamic market by overcoming the challenges and expediting business growth through a strategic and tactical approach.

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DelveInsight Business Research is a leading Market Research, and Business Consultant focused purely on Healthcare. It helps pharma companies by providing them with end-to-end services to solve their business problems.

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